Organometallic Compounds
Medchemexpress LLC Bis-PEG3-NHS ester | 1314378-16-9 | MFCD20227484 | 97.0% | 444.39 g·mol⁻¹ | C18H24N2O11 | 100 MG
Bis-PEG3-NHS ester is a noncleavable, three-unit polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester termini for amine coupling. It is intended for antibody-agent conjugation and related bioconjugation chemistries, enabling formation of stable amide bonds to primary amines on proteins or small molecules.
- Noncleavable three-unit PEG spacer suitable for antibody-agent conjugation and bioconjugation.
- Two NHS ester reactive termini for efficient amine coupling to primary amines.
- White to off-white solid, convenient for bench handling.
- High purity (97.0%) with CAS 1314378-16-9 and formula C18H24N2O11.
- Storage: powder at -20°C (stable up to 3 years); in solvent at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Biotin-PEG3-SS-azide | 2866429-93-6 | 99.6% | 692.91 | C27H48N8O7S3 | 10 MG
Biotin-PEG3-SS-azide is a cleavable three-unit polyethylene glycol linker bearing a biotin group and a terminal azide, designed for conjugation chemistry in research applications. It is suitable for click chemistry reactions and as a cleavable linker in the synthesis of antibody-drug conjugates.
- Cleavable disulfide linker provides intracellular release.
- Azide functionality enables CuAAC and strain-promoted cycloaddition.
- PEG3 spacer increases solubility and reduces steric hindrance.
- High purity supports reliable conjugation results.
- Soluble in DMSO at high concentration for in vitro use.
- Recommended storage at low temperature and protection from light to preserve stability.
Medchemexpress LLC M-PEG5-acid | 81836-43-3 | MFCD20926398 | 95.0% | 280.31 g/mol | C12H24O7 | 1 G
m-PEG5-acid is a monomethylated polyethylene glycol (PEG) linker terminated with a carboxylic acid group, used as a short spacer in the synthesis of PROTACs and other bioconjugates. It provides a PEG5 (approximately five ethylene oxide units) spacer with a reactive carboxylic acid for standard coupling chemistries.
- Short monomethylated PEG5 spacer with terminal carboxylic acid.
- Useful as a linker in PROTAC and conjugate synthesis.
- Molecular weight ~280.31 g/mol and formula C12H24O7.
- Typical purity around 95.0%.
- Light yellow to light brown liquid; density ~1.107 g/cm3.
- Store sealed, away from moisture; use cold storage for solutions.
eMolecules 252881-74-6 | NH2-PEG3-C2-Boc | Ambeed | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 100mg | 506388578
NH2-PEG3-C2-Boc | Ambeed | 252881-74-6 | MFCD06201017 | 277.361 | C13H27NO5 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCN | 100mg | 506388578
Medchemexpress LLC Bromoacetamido-PEG3-azide | 940005-81-2 | ≥97.0% | C10H19BrN4O4 | 50 MG
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent containing an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC M-PEG3-azide | 74654-06-1 | 98.0% | C7H15N3O3 | 500 MG
m-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Participates in CuAAc reactions with Alkyne groups
- Participates in SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC Bis-PEG5-acid 10g | 439114-13-3 | 338.35 g/mol | C14H26O9 | 10 G
Bis-PEG5-acid is a polyethylene glycol (PEG) linker with two terminal carboxylic acid groups used to assemble PROTACs and other bifunctional molecules. The hydrophilic spacer increases aqueous solubility and provides flexible separation between ligands for conjugation chemistry.
- Two terminal carboxylic acid groups for conjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- Flexible linker suitable for PROTAC and bifunctional molecule assembly.
- Available in multiple package sizes including 10 G.
- Solid material with white to yellow appearance.
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202088.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (oxyamine) group and an azide group. It is used as a non-cleavable three-unit PEG spacer for antibody-drug conjugate (ADC) and PROTAC synthesis, and as an azide reagent for click chemistry reactions such as CuAAC and SPAAC.
- Bifunctional aminooxy and azide groups for oxime ligation and click chemistry.
- Non-cleavable three-unit PEG spacer suitable for ADC and PROTAC linker installation.
- Purity 95.0% and molecular weight 234.25 g/mol.
- Appearance colorless to light yellow liquid for easy handling.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Available in small pack sizes, including 10 mg for small-scale synthesis.
Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | MFCD30471718 | ≥98.0% | 264.43 g/mol | C12H28O4Si | 250 MG
TBDMS-PEG3-OH is a tert-butyldimethylsilyl (TBDMS)-protected PEG3 alcohol used as a linker or spacer in organic synthesis, PROTAC construction, and drug-delivery conjugation. It provides a protected terminal alcohol for selective deprotection and coupling reactions.
- Provides a TBDMS-protected terminal alcohol for selective deprotection and coupling.
- Suitable as a PEG3 linker or spacer in medicinal chemistry and PROTAC synthesis.
- High purity (≥98%) and molecular weight 264.43 g/mol.
- Liquid, colorless to light yellow, convenient for solution-phase reactions.
- Recommended storage: pure form -20°C (long term) or 4°C (short term); in solvent store at -80°C.
Medchemexpress LLC NH-bis(PEG3-azide) | 1258939-39-7 | 98.0% | C16H33N7O6 | 250 MG
NH-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Functions as a click chemistry reagent
- Contains an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Capable of strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Bromoacetamido-PEG3-NH-Boc | 1421933-39-2 | C15H29BrN2O6 | 5 G
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker.
- Can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system.
- Selectively degrade target proteins.
Medchemexpress LLC Azido-PEG5-triethoxysilane | 3025193-22-7 | MFCD31693730 | 95.0% | C22H46N4O9Si | 25 MG
Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, which allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an Azide group for copper-catalyzed azide-alkyne cycloaddition reactions.
- Can undergo strain-promoted alkyne-azide cycloaddition reactions.
- PROTACs enable selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
Medchemexpress LLC THP-PEG5-OH | 146395-14-4 | 25 MG
THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also described as a reference compound.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Reference compound
Medchemexpress LLC NH2-PEG5-C6-Cl hydrochloride | 2241669-16-7 | 98.0% | 100 MG
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteasome system
- For selective degradation of target proteins
Medchemexpress LLC BnO-PEG5-OH | 57671-28-0 | 98.6% | 328.40 g/mol | C17H28O6 | 10 G
BnO-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker used to connect ligands in proteolysis targeting chimera (PROTAC) synthesis, providing spacer functionality and flexibility to aid target engagement and E3 ligase recruitment.
- Polyethylene glycol spacer with five ethylene glycol units.
- High purity suitable for research applications.
- Liquid, colorless to light yellow, density ≈ 1.10 g/cm3.
- Stable under recommended storage conditions for pure material and in solvent.
- Available in common laboratory pack sizes, including 10 g.